C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 7/42 (2006.01) A61K 31/70 (2006.01) C07C 59/60 (2006.01) C07H 3/06 (2006.01) C07H 13/12 (2006.01) C12N 1/20 (2006.01)
Patent
CA 2135041
Abstract MA having a hydroxylated or oxidized lipid side chain and moenomycin analogs, a process for preparation and the use of these compounds The invention relates to MA of the formula I Image I in which R1,R2,R4 and R5 independently of one another are a hydroxyl group or hydrogen and R3 is hydrogen, the bond between the carbon atom carrying the substituent R4 and the carbon atom carrying the substituent R5 being a single bond, or R1 and R2 independently of one another are a hydroxyl group or hydrogen and R3 is hydrogen, the bond between the carbon atom carrying the substituent R4 and the carbon atom carrying the substituent R5 being a double bond, or R1,R2 and R5 independently of one another are a hydroxyl group or hydrogen and R3 and R4 together are an oxo group MA is hydroxylated or oxidized in the lipid side chain by microorganisms of the genus Cryptococcus and in this form is a starting compound for the preparation of moenomycin analogs which can be employed as pharmaceuticals. The moenomycin analogs have the following chemical structure: Image II in which R1 to R5 have the abovementioned meaning>
Aretz Werner
Hedtmann Udo
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Aktiengesellschaft
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