Methods for treating neuropsychiatric disorders

Details Methods for treating neuropsychiatric disorders Methods for treating neuropsychiatric disorders

A - Human Necessities

61

K

A61K 31/198 (2006.01) A61K 45/06 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2328197

The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, close head injury, and attention deficit disorder. The methods entail administering to a patient diagnosed as having a neuropsychiatric disorder a pharmaceutical composition containing (i) a therapeutically effective amount of D-alanine (or a modified form thereof), provided that the composition is substantially free of D-cycloserine, and/or (ii) D-serine (or a modified form thereof), and/or (iii) 105 to 500 mg of D-cycloserine (or a modified form thereof), and/or (iv) N-methylglycine (or a modified form thereof).

L'invention concerne des méthodes de traitement de troubles neuropsychiatriques tels que la schizophrénie, la maladie d'Alzheimer, l'autisme, la dépression, les pertes de mémoire bénignes, les difficultés scolaires chez l'enfant, les lésions crâniennes fermées et le trouble déficitaire de l'attention. Les méthodes consistent à administrer à un patient, chez lequel on a diagnostiqué un trouble neuropsychiatrique, une composition pharmaceutique contenant : (i) une quantité efficace sur le plan thérapeutique de D-alanine (ou une forme modifiée de D-alanine), à condition que la composition soit sensiblement exempte de D-cyclosérine ; et/ou (ii) D-sérine (ou une forme modifiée de D-sérine) ; et/ou (iii) 105 à 500 mg de D-cyclosérine (ou une forme modifiée de D-cyclosérine) ; et/ou (iv) N-méthylglycine (ou une forme modifiée de N-méthylglycine).

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