C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2598454
The invention pertains to anti-PSMA antibodies that lack fucosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity as compared to the fucosylated form of the antibodies. The invention also provides host cells that express the anti-PSMA antibodies that lack fucosyl residues, wherein the host cells are deficient for a fucosyl transferase. Methods of using the antibodies to inhibit the growth of PSMA+ cells, such as tumor cells, are also provided.
La présente invention concerne des anticorps anti-PSMA qui sont dépourvus de résidus fucosyle. Les anticorps selon l'invention présentent une plus forte activité de cytotoxicité cellulaire dépendant des anticorps que la forme fucosylée des anticorps. Cette invention concerne également des cellules hôtes qui expriment les anticorps anti-PSMA dépourvus de résidus fucosyle, lesdites cellules hôtes étant déficientes en fucosyl transférase; et des méthodes d'utilisation desdits anticorps pour inhiber la croissance des cellules PSMA+, telles que les cellules tumorales.
Albanese Jenny
Cardarelli Josephine M.
Passmore David B.
Zhu Lei
Borden Ladner Gervais Llp
Medarex Inc.
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