C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/02 (2006.01) A61K 39/12 (2006.01) A61K 39/125 (2006.01) A61K 39/145 (2006.01) A61K 39/205 (2006.01) C07K 14/555 (2006.01) C12N 7/00 (2006.01) C12N 15/67 (2006.01) C12P 21/02 (2006.01) C12Q 1/18 (2006.01) C12Q 1/70 (2006.01)
Patent
CA 2229163
Methods for enhancing the production of viral vaccines in animal cell culture are described. These methods rely on the manipulation of the cellular levels of certain interferon induced antiviral activities, in particular, cellular levels of double-stranded RNA (dsRNA) dependent kinase (PKR) and 2'-5' oligoadenylate synthetase (2-5A synthetase). In cell cultures deficient for PKR or 2-5A synthetase, viral yield is enhanced by several orders of magnitude over cell cultures with normal levels of these proteins making these cell cultures useful for the production of viral vaccines.
L'invention porte sur des procédés permettant d'améliorer la production de vaccins antiviraux dans une culture cellulaire animale. Ces procédés reposent sur la manipulation des taux, dans les cellules, de certaines activités antivirales induites par un interféron, notamment, de ceux de la kinase (PKR) dépendante d'ARN double brin et de la 2'-5' oligo-adénylate synthétase (synthétase 2-5A). Dans des cultures cellulaires déficitaires en PKR ou en synthétase 2-5A, on accroît de plusieurs ordres de grandeur la production du virus par rapport à celle de cultures cellulaires dont les taux cellulaires de ces protéines sont normaux, ce qui les rend des plus aptes à la production de vaccins antiviraux.
Smart & Biggar
The Regents Of The University Of California
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