C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/06 (2006.01) A61K 31/40 (2006.01) A61P 15/10 (2006.01) A61P 25/24 (2006.01) C07D 207/08 (2006.01) C07D 207/09 (2006.01)
Patent
CA 2356065
The invention provides compounds of general formula (I) wherein R1 is H or C1- C6 alkyl; R2 and R3, together with the interconnecting atoms form a 4 to 8- membered saturated ring containing one or two heteroatoms (including the nitrogen to which R2 is attached) wherein a second heteroatom, if present, is selected from oxygen, nitrogen and sulfur, with the proviso that said ring cannot contain two adjacent heteroatoms; Z is CF3, OCF3, C1-C6alkylthio or C1- C6alkoxy; Y is hydrogen, halogen, -OR a, R a or C1-C6alkylthio, and wherein R a is C1- C4 alkyl optionally substituted with fluorine atoms; or when Z and Y are attached para and meta to the ether linkage linking rings A and B, Z and Y are linked so that, together with the interconnecting atoms, Z and Y form a fused 5 to 7-membered carbocyclic or heterocyclic ring which may be saturated, unsaturated or aromatic, and wherein when Z and Y form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; and Z and Y together do not form a fused phenyl ring; R4 and R5, which may be the same or different, are: A-X, wherein A = -CH=CH- or -(CH2)p- where p is 0, 1 or 2; X is hydrogen, F, Cl, Br, I, CONR6R7, SO2NR6R7, SO2NHC(=O)R6, OH, C1-4alkoxy, NR8SO2R9, NO2, NR6R11, CN, CO2R10, CHO, SR10, S(O)R9 or SO2R10; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R13; wherein R13 is hydroxy, C1-C4alkoxy, F, C1-C6alkyl, haloalkyl, haloalkoxy, -NH2, -NH(C1-C6alkyl) or -N(C1-C6alkyl)2, (see formula I) and their use in the treatment of disorders that can be prevented, ameliorated or cured by the regulation of monoamine transporter function.
Andrews Mark David
Hepworth David
Middleton Donald Stuart
Stobie Alan
Bereskin & Parr
Limited Pfizer
LandOfFree
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