Substituted cyclopropylamino-1,3,5-triazines

Details Substituted cyclopropylamino-1,3,5-triazines Substituted cyclopropylamino-1,3,5-triazines

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 251/18 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 411/04 (2006.01) C07D 417/04 (2006.01) C07D 498/08 (2006.01)

Patent

CA 2072680

ABSTRACT New substituted cyclopropylamino-1,3,5-triszines having the formula Image (I) wherein R1 is C1-C3-alkyl, C3-C5 cycloalkyl or C1-C3-alkyl-C3-C5-cycloalkyl R2 is bis(2-hydroxyethyl)amino, 3-hydroxy l-azetidinyl, 3-methoxy-1- azetidinyl, 3-oxo-1-azetidinyl, morpholino, 4-hydroxypiperidino, thiomorpholino, thiomorpholino S-oxide, thiomorpholino S,S- dioxide, 3-thiazolidinyl, 3-thiazolidinyl S-oxide, 3- thiazolidinyl S,S-dioxide or 8-oxa-3-azabicyclo[3,2,1]oct-3-yl. Processes for the preparation thereof and pharmaceutical composition containing them are also given. The compounds are useful for the treatment of disorders associated with Alzheimer's disease, senile dementia, Alzheimer's type and with any evolutive cognitive pathology, and also for the treatment of depression, anxiety, mood disturbances, inflammatory phenomena and asthma.

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