Transcriptionally-activated aav inverted terminal repeats...

Details Transcriptionally-activated aav inverted terminal repeats... Transcriptionally-activated aav inverted terminal repeats...

C - Chemistry, Metallurgy

12

N

C12N 15/864 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/67 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2304801

This invention provides transcriptionally-activated AAV ITRs (inverted terminal repeats) which are small and transcriptionally active and uses thereof to optimize the expression of relatively large transgenes packaged in recombinant AAV vectors.

Cette invention se rapporte à des séquences terminales répétées inverses (ITR) de virus adéno-associés (AAV) à action transcriptionnelle qui sont de petite taille et produisent une action transcriptionnelle, ainsi qu'à leurs utilisations en vue d'optimiser l'expression de trangènes de taille relativement grande incorporés dans des vecteurs d'AAV de recombinaison.

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