Microparticles with adsorbed polypeptide-containing molecules

Details Microparticles with adsorbed polypeptide-containing molecules Microparticles with adsorbed polypeptide-containing molecules

A - Human Necessities

61

K

A61K 39/385 (2006.01) A61J 3/02 (2006.01) A61K 9/16 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 47/30 (2006.01) A61K 47/48 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2476626

Microparticles with adsorbed polypeptide-containing molecules formed without the use of surfactant, methods of making such microparticle compositions, and uses thereof, are disclosed. The microparticles comprise a polymer, such as a poly(.alpha.-hydroxy acid), a polyhydroxy butyric acid, a polycaprolactone, a polyorthoester, a polyanhydride, and the like. Preferred polymers are poly(D,L- lactide-co-glycolides), more preferably those having a lactide/glycolide molar ratio ranging from 40:60 to 60:40 and having a molecular weight ranging from 20,000 Daltons to 70,000 Daltons. Preferred polypeptide~ containing molecules are bacterial and viral antigens (including HIV antigens, meningitis B antigens, streptococcus B antigens, and Influenza A hemagglutinin antigens).

L'invention concerne des microparticules comprenant des mol~cules adsorb~es qui contiennent des polypeptides obtenues sans utiliser de tensioactif, des m~thodes de fabrication de ces compositions de microparticules ainsi que les utilisations de ces derni­res. Les microparticules selon l'invention comprennent un polym­re, telles qu'un poly(acide ?-hydroxy), un acide polyhydroxybutyrique, un polycaprolactone, un polyorthoester, un polyanhydride, etc. De pr~f~rence, les polym­res pr~f~r~s sont des poly(D,L-lactide-co-glycolides), id~alement ceux qui pr~sentent un rapport molaire lactide/glycolide compris entre 40:60 et 60:40 et qui pr~sentent un poids mol~culaire compris entre 20.000 Daltons et 70.000 Daltons. De pr~f~rence, les mol~cules qui contiennent des polypeptides sont des antig­nes bact~riens et viraux (notamment des antig­nes de HIV, des antig­nes de m~ningite B, des antig­nes de streptocoque B et des antig­nes h~magglutinine de grippe A).

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