Substituted oxazole ketone modulators of fatty acid amide...

Details Substituted oxazole ketone modulators of fatty acid amide... Substituted oxazole ketone modulators of fatty acid amide...

C - Chemistry, Metallurgy

07

D

C07D 263/34 (2006.01) A61K 31/421 (2006.01)

Patent

CA 2663075

Certain oxazole ketone compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).

L'invention concerne certains composés de cétone d'oxazole qui sont utilisés comme inhibiteurs d'une hydrolase des amides d'acides gras (FAAH, "fatty acid amide hydrolase"). On peut utiliser ces composés dans des compositions pharmaceutiques et des méthodes de traitement de problèmes de santé, de troubles et d'états médiés par une activité induite par FAAH. On peut ainsi administrer lesdits composés pour traiter, par ex., l'anxiété, la douleur, les inflammations, les troubles du sommeil, les troubles de l'alimentation ou les troubles du mouvement (tels que la sclérose en plaques).

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