Fibroblasts for the treatment of muscular disorders

Details Fibroblasts for the treatment of muscular disorders Fibroblasts for the treatment of muscular disorders

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 35/36 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2198379

Muscular disorders such as Duchenne muscular dystrophy are alleviated by introducing dermal fibroblasts (which may be the patient's own), into the muscle. In vivo fusion of the donor cells with each other converts them into muscle cells, which produce the products of muscle-specific genes such as dystrophin and other muscle proteins. The donor fibroblasts may contain muscle- specific DNA.

On traite des affections musculaires telles que la dystrophie musculaire de Duchenne en introduisant dans le muscle des fibroblastes dermiques (qui peuvent être ceux du patient lui-même). La fusion in vivo des cellules donatrices entre elles convertit celles-ci en cellules musculaires, lesquelles expriment les produits des gènes spécifiques du muscle, tels que la dystrophine ainsi que d'autres protéines musculaires. Les fibroblastes donneurs peuvent contenir de l'ADN spécifique du muscle.

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