C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01)
Patent
CA 2732856
The invention relates to the field of recombinant antibodies for use in human cancer therapy. More specifically the invention provides the use of an antibody composition with two distinct non- overlapping binding specificities to human EGFR. The antibody composition is effecting in treating cancer following treatment with other anti-EGFR antibodies, whether the cancer shows progression during or following the prior treatment or not. The antibody composition can also be used for repeated treatment of recurrent tumours following first-line therapy with the antibody composition of the invention, as the composition does not lead to selection of resistant tumours. A further therapeutic use is the use of an antibody composition of the invention for treatment of cancer that is resistant to known anti-EGFR antibodies.
L'invention, du domaine des d'anticorps de recombinaison utilisés en thérapie anti-cancer humaine, porte plus spécifiquement sur l'utilisation d'une compositions de ces anticorps à deux spécificités distinctes non recouvrantes de fixation au susdit récepteur EGFR. La composition s'avère efficace dans le traitement de cancers suite à un traitement par d'autres anticorps anti-EGFR, et cela que le cancer progresse ou non pendant ou après un premier traitement. On peut utiliser la composition pour le traitement répétitif de tumeurs récurrentes suite à une thérapie de première ligne par cette même composition, puisqu'elle ne conduit pas à la sélection de tumeurs résistantes. Une autre utilisation thérapeutique de la composition de l'invention est le traitement de cancers résistants à d'autres anticorps anti-EGFR.
Hey Adam S.
Jacobsen Helle
Kragh Michael
Pedersen Mikkel Wandahl
Borden Ladner Gervais Llp
Symphogen A/s
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