Novel synergistic effects

Details Novel synergistic effects Novel synergistic effects

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2727278

The present invention encompasses a combination of at least one conjugate and one or more chemotherapeutic agent(s) which when administered exerts an unexpectedly enhanced therapeutic effect The therapeutic effectiveness of the combi-nation is greater than that of the conjugate alone or the administration of one or more of the drug(s) without the conjugate The present invention is also directed to compositions comprising at least one conjugate and at one or more of chemotherapeutic agent and to methods of treating cancer using at least one conjugate and at least one or more of chemotherapeutic agent (s) The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of one or more chemotherapeutic agent(s) and at least one conjugate In each case, such combina-tion has therapeutic synergy or improves the therapeutic index in the treatment of cancer over the anticancer agent(s) alone

La présente invention concerne une combinaison dau moins un conjugué et un ou plusieurs agent(s) chimiothérapeutique(s) qui, lorsquelle est administrée, exerce un effet thérapeutique amélioré inattendu. Lefficacité thérapeutique de la combinaison est supérieure à celle du conjugué seul ou à ladministration dun ou plusieurs des médicament(s) sans le conjugué. La présente invention concerne en outre des compositions comprenant au moins un conjugué et au moins un ou plusieurs agent(s) chimiothérapeutique(s) et des procédés de traitement du cancer utilisant au moins un conjugué et au moins un ou plusieurs agent(s) chimiothérapeutique(s). La présente invention concerne en outre des procédés de modulation de la croissance de populations de cellules sélectionnées, telles que des cellules cancéreuses, par administration dune quantité thérapeutiquement efficace dun ou plusieurs agent(s) chimiothérapeutique(s) et au moins un conjugué. Dans chaque cas, une telle combinaison a une synergie thérapeutique ou améliore lindice thérapeutique dans le traitement du cancer par rapport aux agent(s) anticancéreux seul(s).

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