Compositions and methods for treatment of eye disorders

A - Human Necessities – 61 – K

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A61K 31/166 (2006.01)

Patent

CA 2609053

The present invention provides compounds and methods for the treatment of LFA- 1 mediated diseases. In particular, LFA-1 antagonists are described herein and these antagonists are used in the treatment of LFA-1 mediated diseases. One aspect of the invention provides for diagnosis of an LFA-1 mediated disease and administration of a LFA-1 antagonist, after the patien is diagnosed with a LFA-1 mediated disease. In some embodiments, the LFA-1 mediated diseases treated are dry eye disorders. Also provided herein are methods for identifying compounds which are LFA-1 antagonists.

Cette invention concerne des composés et des procédés servant à traiter les maladies médiées par LFA-1. Cette invention décrit en particulier des antagonistes de LFA-1, qui sont utilisés dans le traitement des maladies médiées par LFA-1. Dans l'un de ses aspects, cette invention prévoit le diagnostic d'une maladie médiée par LFA-1 et l'administration d'un antagoniste de LFA-1, après qu'une maladie médiée par LFA-1 a été diagnostiquée chez le patient. Dans certains modes de réalisation, les maladies médiées par LFA-1 ainsi traitées sont les troubles oculaires liés à une insuffisance lacrymale. Cette invention concerne également des procédés pour identifier des composés constituant des antagonistes de LFA-1.

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