Recombinant rabies vaccine and methods of preparation and use

Details Recombinant rabies vaccine and methods of preparation and use Recombinant rabies vaccine and methods of preparation and use

A - Human Necessities

61

K

A61K 39/205 (2006.01)

Patent

CA 2463090

Live rabies virus vaccines comprising a recombinant rabies virus genome which overexpresses the rabies virus G protein increase apoptotic activity in infected cells, and enhance the generation of anti-rabies immunity in a subject.

L'invention concerne des vaccins antirabiques à virus vivants comprenant un génome recombiné de virus de la rage qui provoque une surexpression de la protéine G du virus de la rage. Ces vaccins augmentent l'activité apoptotique dans les cellules infectées et entraînent l'apparition d'une immunité antirabique chez le sujet.

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