Methods and kits for use in preventing restenosis

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/18 (2006.01) A61K 33/00 (2006.01) A61K 33/14 (2006.01) A61K 33/20 (2006.01)

Patent

CA 2393261

Kits and methods for their use are provided for at least inhibiting the progression of, if not preventing, restenosis in a host. In the subject methods, a vascular site is contacted, usually flushed, with a solution having a pH that is less than about 4, e.g. a hydrochloric acid. The subject kits methods find use in applications where the prevention of restenosis is desirable, including angioplasty applications, and may be used in combination with other treatment modalities, e.g. stents, and the like.

Cette invention se rapporte à des kits et à des procédés servant au moins à empêcher la progression de la resténose, à défaut de la prévenir, dans un organisme hôte. Dans ces procédés, un site vasculaire est mis en contact, habituellement par rinçage, avec une solution ayant un pH inférieur à environ 4, par exemple de l'acide chlorhydrique. Ces procédés et ces kits trouvent des applications dans les situations où la prévention de la resténose est souhaitable, par exemple dans l'angioplastie, et ils peuvent également être utilisés en association avec d'autres modes de traitement, tels que des extenseurs vasculaires et similaires.

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