Mouse deficient in glutamate transporter glast function

Details Mouse deficient in glutamate transporter glast function Mouse deficient in glutamate transporter glast function

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A01K 67/027 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2522597

It is intended to provide a GLAST knockout mouse lacking the function of endogenous glutamate transporter GLAST gene which shows: 1) an ocular tension within the normal range; and 2) a decrease in retinal ganglion cell count compared with a normal wild type mouse. Owing to the ocular properties, this knockout mouse is useful as a normal tension glaucoma model. By using this knockout mouse, a compound useful in treating normal tension glaucoma can be screened.

L'invention concerne une souris knockout GLAST, présentant une déficience au niveau de la fonction du gène GLAST du transporteur de glutamate endogène, montrant : 1) une tension oculaire à l'intérieur de la plage normale, et 2) une diminution dans le décompte cellulaire du ganglion rétinal en comparaison avec celui d'une souris de type sauvage normale. En raison de ces propriétés oculaires, cette souris knockout est utilisée en tant que modèle de glaucome de tension normale. L'utilisation de cette souris knockout permet de cribler un composé utile pour le traitement du glaucome de tension normale.

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