G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) A61K 38/21 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2504980
Methods for identifying and providing new therapeutic agent(s) by selecting at least one polypeptide encoded by a natural allelic variant of one preselected gene having a therapeutic potential; determining the therapeutic index of the selected polypeptide(s) and retaining as therapeutic agent(s) those polypeptide(s) whose therapeutic index is higher than that of a reference agent. The therapeutic indices of antiviral, anti-proliferative and immunomodulatory activities as well as toxicity are determined for members of the IFN.alpha. gene family.
La présente invention concerne des procédés pour identifier et fournir un nouvel/de nouveaux agent(s) thérapeutique(s) par sélection d'au moins un polypeptide codé par une variante allélique naturelle d'un gène présélectionné ayant un potentiel thérapeutique, détermination de l'indice thérapeutique du/des polypeptide(s) sélectionné(s), et conservation comme agent(s) thérapeutique(s) du/des polypeptide(s) dont l'indice thérapeutique est supérieur à celui d'un agent de référence.
Genodyssee
Robic
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