Heterocyclic cis cyclopropane derivatives as melatonergic...

Details Heterocyclic cis cyclopropane derivatives as melatonergic... Heterocyclic cis cyclopropane derivatives as melatonergic...

A - Human Necessities

61

K

A61K 31/44 (2006.01) A01N 43/08 (2006.01) A01N 43/30 (2006.01) A01N 43/32 (2006.01) A61K 31/335 (2006.01) A61K 31/36 (2006.01) C07D 307/79 (2006.01) C07D 307/88 (2006.01) C07D 317/46 (2006.01) C07D 319/04 (2006.01) C07D 319/08 (2006.01)

Patent

CA 2334299

There is provided a novel series of cis cyclopropane compounds of Formula (I), wherein R1, R2, R3, R4, X, Y, Z and m are as defined herein which bind to the human melatonin receptor and therefore are useful as melatonergic agents.

Cette invention porte sur une série de composés cis de cyclopropane représentés par la formule générale (I). En l'occurrence, R?1¿, R?2¿, R?3¿, R?4¿, X, Y, Z et m sont tels que définis dans la demande. Se liant au récepteur humain de la mélatonine, ces composés conviennent comme mélatonergiques.

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