A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 37/18 (2006.01) A01N 43/04 (2006.01) A61K 38/19 (2006.01) A61K 38/57 (2006.01) C07H 21/04 (2006.01) C07K 14/50 (2006.01) C07K 14/52 (2006.01) C07K 14/81 (2006.01) C07K 16/22 (2006.01) C07K 16/24 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2300964
Vascular endothelial growth factor-B (VEGF-B) and vascular endothelial growth factor-C (VEGF-C) are angiogenic polypeptides. It has been shown that VEGF-B and -C are angiogenic in vitro especially in combination with bFGF. VEGF-C also increases plasminogen activator (PA) activity in bovine endothelial cell lines and this is accompanied by a concomitant increase in PA inhibitor-1. Addition of alpha-2-antiplasmin to bovine endothelial cells co-treated with bFGF and VEGF-C partially inhibits collagen gel invasion.
Le facteur B de croissance endothéliale vasculaire (VEGF-B) et le facteur C de croissance endothéliale vasculaire (VEGF-C) sont des polypeptides angiogéniques. On a découvert que VEGF-B et VEGF-C sont angiogéniques in vitro plus particulièrement en combinaison avec b(FGF). VEGE-C augmente aussi l'activité des activateurs du plasminogène (PA) et ceci s'accompagne d'une augmentation correspondante de l'inhibiteur-1 PA. L'apport d'alpha-2-antiplasmine aux cellules endothéliales bovines traitées conjointement avec bFGF et VEGF-C permet d'inhiber partiellement l'invasion de gel collagène.
Alitalo Kari
Eriksson Ulf
Pepper Michael S.
Helsinki University Licensing Ltd. Oy
Ludwig Institute For Cancer Research
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
University Of Geneva
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