Method of treating cancer using a neuropeptide y 5r (np y5r)...

A - Human Necessities – 61 – K

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Details

A61K 31/4355 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2717904

The present invention relates to methods for treating cancer by administering a therapeutically effective amount of compound of formula (I), such as selective NPY5R antagonist MK-0557( trans -N- [1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6- azaisobenzofuran-1(3H), 1'- cyclohexane]-4'-carboxamide ), or a pharmaceutically acceptable salt thereof, to a subject in need thereof The methods can further comprise administering a chemotherapeutic agent to the subject in need thereof.

La présente invention porte sur des procédés pour traiter le cancer par l'administration à un sujet qui en a besoin d'une quantité thérapeutiquement efficace d'un composé de formule (I), tel qu'un antagoniste de NPY5R sélectif MK-0557 (trans-N-[1-(2-fluorophényl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide), ou son sel pharmaceutiquement acceptable. Les procédés peuvent en outre comprendre l'administration d'un agent chimiothérapeutique au sujet qui en a besoin.

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