C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/14 (2006.01) A61K 31/501 (2006.01) A61P 25/22 (2006.01) A61P 25/28 (2006.01) C07D 405/12 (2006.01)
Patent
CA 2461510
The invention relates to new substituted alkylaminopyridazinone derivatives of the general Formula (I), (wherein R1 is hydrogen or alkyl having 1-4 carbon atoms; one of X and Y stands for hydrogen or halogen and the other represents a group of the general Formula (II), R2 is hydrogen or alkyl having 1-4 carbon atoms; n is 1, 2 or 3; R3 stands for hydrogen, alkyl having 1-4 carbon atoms or aryl-(C1-4 alkyl); Z stands for oxygen; or R3 and Z together with the groups placed between them form a piperazine ring; and R4 stands for hydrogen, halogen, trifluoromethyl or alkoxy having 1-4 carbon atoms) and pharmaceutically acceptable acid addition salts thereof. The invention compounds are useful in the treatment of anxiolytic conditions and cognitive disorders.
L'invention concerne de nouveaux dérivés d'alkylaminopyridazinone correspondant à la formule générale (I), dans laquelle R¿1? est hydrogène ou alkyle possédant 1-4 atomes de carbone; parmi X et Y, l'un des deux indique l'hydrogène ou l'halogène, et l'autre indique un groupe correspondant à la formule générale (II), R¿2? est alkyle d'hydrogène possédant 1-4 atomes de carbone; n est 1, 2 ou 3; R¿3? représente hydrogène, alkyle possédant 1-4 atomes de carbone s ou aryl-(alkyle C¿1-4?); Z indique l'oxygène; ou R¿3? et Z avec les groupes placés entre eux forment un anneau de pipérazine; et R¿4? indique l'hydrogène, l'halogène, l'alkyle ou l'alcoxy de trifluorométhyle possédant 1-4 atomes de carbone, et leurs sels d'addition acides pharmaceutiquement acceptables. Les composés de l'invention sont utiles dans le traitement des états anxiolytiques et des troubles cognitifs.
Barkoczy Jozsef
Egyed Andras
Gacsalyi Istvan
Harsing Laszlo Gabor
Kompagne Hajnalka
Egis Gyogyszergyar Rt.
Robic
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