C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/04 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2249542
The present invention relates to pyrazole derivatives of the formula I (see fig. I) in which X, R1, R1a, R2, R3, R4 and n are as defined in the claims, which are useful pharmaceutically active compounds for the therapy and prophylaxis of illnesses, for example of cardiovascular diseases such as hypertension, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I are capable of modulating the body's production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the therapy and prophylaxis of illnesses which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the formula I, to their use for the therapy and prophylaxis of the abovementioned illnesses and for preparing pharmaceuticals for this purpose, and also to pharmaceutical preparations which comprise the compounds of the formula I.
L'invention concerne des dérivés de pyrazole de la formule I (voir fig. I), dans laquelle X, R1, R1a, R2, R3, R4 et n sont tels que définis dans les revendications, qui sont des composés ayant une activité pharmaceutique et qui sont utiles pour traiter et prévenir les maladies, par exemple, les maladies cardio-vasculaires comme l'hypertension, l'angine de poitrine, l'insuffisance cardiaque, les thromboses ou l'athérosclérose. Les composés de la formule I sont capables de moduler la production par le corps de guanosine-monophosphate cyclique (GMPc) et conviennent généralement pour traiter et prévenir les maladies associées à un déséquilibre du GMPc. L'invention a aussi trait à des procédés pour préparer des composés de la formule I, à leur utilisation pour traiter et prévenir les maladies susmentionnées et pour préparer des produits pharmaceutiques à cette fin, ainsi qu'aux préparations pharmaceutiques qui comprennent les composés de la formule I.
Schindler Ursula
Schonafinger Karl
Strobel Hartmut
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Marion Roussel Deutschland Gmbh
Sanofi-Aventis Deutschland Gmbh
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