New compositions and methods for cell killing

Details New compositions and methods for cell killing New compositions and methods for cell killing

A - Human Necessities

01

N

A01N 61/00 (2006.01) A01N 25/10 (2006.01) A01N 25/34 (2006.01) A01P 1/00 (2006.01) A01P 15/00 (2006.01) A61K 45/00 (2006.01) A61L 2/16 (2006.01) A61L 27/34 (2006.01)

Patent

CA 2682930

The present invention discloses an insoluble proton sink or source (PSS), useful for killing living target cells (LTCs), or otherwise disrupting vital intracellular processes and/or intercellular interactions of the LTC upon contact. The PSS comprises (i) proton source or sink providing a buffering capacity; and (ii) means providing proton conductivity and/or electrical potential. The PSS is effectively disrupting the pH homeostasis and/or electrical balance within the confined volume of the LTC and/or disrupting vital intercellular interactions of the LTCs while efficiently preserving the pH of the LTCs' environment. The invention also provides articles of manufacture comprises the PSS and presents an effective method for killing the LTCs.

La présente invention concerne un puits ou une source de protons insoluble (PSS), utile pour détruire des cellules cibles vivantes (LTC), ou autrement interrompre des processus intracellulaires vitaux et/ou des interactions intracellulaires vitales des LTC lors d'un contact. Le PSS comprend (i) une source ou un puits de protons fournissant une capacité de tamponnement; et (ii) des moyens assurant une conductivité de protons et/ou un potentiel électrique. Le PSS perturbe efficacement l'homéostasie de pH et/ou l'équilibre électrique à l'intérieur du volume confiné des LTC et/ou perturbe des interactions intercellulaires vitales des LTC tout en préservant efficacement le pH de l'environnement des LTC. L'invention concerne également des articles de fabrication qui comprennent le PSS et présente un procédé efficace pour détruire les LTC.

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