Modulating binding site on potassium channels used for...

Details Modulating binding site on potassium channels used for... Modulating binding site on potassium channels used for...

G - Physics

01

N

G01N 33/68 (2006.01)

Patent

CA 2380489

The invention relates to a novel selective modulating binding site on the potassium channel with the subunits KCNQ2 and KCNQ3 that are characterized by retigabine. This novel binding site can be used to screen and find novel substances for treating diseases that are related to a hyperexcitability or a hypoexcitability of the neuronal cells.

L'invention concerne un nouveau site de fixation de modulation sélective du canal de potassium comprenant les sous-unités KCNQ2 et KCNQ3 et caractérisée par le rétigabine. Ce site permet d'analyser et de détecter de nouveaux principes actifs en vue de traiter les maladies dues à une surexcitation ou à une excitabilité insuffisante des cellules neuronales.

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