A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4045 (2006.01) A61F 13/00 (2006.01) A61K 31/40 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2396129
The invention relates to a pharmaceutical formulation, including both melatonin and at least one antihypertensive compound, as well as a method, for treating a patient who is resistant to antihypertensives in absence of melatonin, a method for lowering nocturnal blood pressure in patients who have an abnormal rhythm in blood pressure in the absence or presence of antihy-pertensives, and a method for imparting in a patient at least one effect selected from improvement in mood and daytime vigilance, postponement of the peak level of cortisol in the patient and potential prophylactic protection against the detrimental effects of is-chemia on the heart, wherein melatonin is administered in an effective amount and manner.
L'invention concerne une formulation pharmaceutique renfermant de la mélatonine et au moins un composé antihypertenseur, et une méthode permettant de traiter un patient résistant aux antihypertenseurs administrés en l'absence de mélatonine ; un procédé permettant d'abaisser la pression artérielle nocturne de patients présentant une pression artérielle anormale en l'absence ou en présence d'antihypertenseurs ; et un procédé permettant de produire sur un patient au moins un effet sélectionné dans le groupe comprenant une amélioration de l'humeur et de la vigilance diurne, un retardement du pic de cortisol chez le patient, et une protection prophylactique potentielle contre les effets nuisibles de l'ischémie sur le coeur. La mélatonine est administrée en quantité efficace et de manière efficace.
Laudon Moshe
Zisapel Nava
Dennison Associates
Neurim Pharmaceuticals (1991) Ltd.
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