Stabilized polymeric thiol reagents

Details Stabilized polymeric thiol reagents Stabilized polymeric thiol reagents

C - Chemistry, Metallurgy

08

G

C08G 65/334 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2591233

Disclosed are water soluble polymeric reagents comprising the structure POLY- [Y-S-W]x,, where POLY is a water soluble polymer; Y is a hydrocarbon~based spacer group, x is 1 to 25, and S-W is a thiol, protected thiol, or thiol- reactive derivative. Preferably, the water soluble polymer is a PEG polymer. Also disclosed are conjugates of such polymeric reagents with pharmaceutically relevant molecules, and methods of their formation and use.

L'invention concerne des réactifs polymères solubles dans l'eau comprenant la structure POLY-[Y-S-W]x, dans laquelle POLY représente un polymère soluble dans l'eau ; Y représente un groupe à bras écarteur à base d'hydrocarbures ; x est compris entre 1 et 25 ; S-W représente thiol, ou un dérivé réactif de type thiol. De préférence, le polymère soluble dans l'eau est un polymère PEG. L'invention concerne également des conjugués des réactifs polymères comprenant des molécules pharmaceutiquement acceptables, et des procédés pour les former et les utiliser.

Affiliated with

Also associated with

Rating

Stabilized polymeric thiol reagents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Stabilized polymeric thiol reagents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stabilized polymeric thiol reagents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1501061