Medicinal compositions for oral use

Details Medicinal compositions for oral use Medicinal compositions for oral use

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/4545 (2006.01) A61P 31/18 (2006.01) C07D 211/62 (2006.01)

Patent

CA 2432527

Medicinal compositions for oral use characterized by comprising a compound having a CCR5 antagonism which has been dissolved or dispersed in an amphiphilic carrier. Because of having an extremely high oral absorbability while showing little scatter in the concentration of the CCR5 antagonistic compound or its salt in blood, these compositions are usable as preparations for oral administration which are efficacious in preventing and treating various HIV infections in humans.

La présente invention concerne des compositions médicinales s'administrant par voie orale, caractérisées en ce qu'elles comprennent un composé présentant un antagonisme contre les CCR5, et qui est dissout ou en dispersion dans un vecteur amphiphile. Du fait de leur absorbabilité par voie orale extrêmement élevée malgré un faible niveau de dispersion dans la concentration du composé antagoniste des CCR5 ou de son sel dans le sang, ces compositions conviennent comme préparations s'administrant par voie orale puissantes dans la prévention et le traitement de diverses infections par le VIH chez les humains.

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