C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 281/10 (2006.01) A61K 31/554 (2006.01) A61P 1/16 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2497345
Drugs useful for the treatment and prevention of hyperlipidemia, moreover drugs useful for the treatment and prevention of cholestasis-caused hepatopathy, particularly primary biliary cirrhosis and primary sclerosing cholangitis, and drugs for the treatment and prevention of obesity, fatty liver and steatohepatitis, containing as active ingredients benzothiazepine compounds having a thioamide bond and a quaternary ammonium substituent, represented by formula (1) below are provided. (See formula 1) Also, drugs containing ileal bile acid transporter inhibiting compounds as active ingredients for the treatment and prevention of cholestasis-caused hepatopathy are provided.
L'invention concerne des médicaments utilisés comme agents prophylactiques et remèdes contre notamment l'hyperlipidémie, des médicaments utilisés comme agents prophylactiques et remèdes contre la cholestase accompagnant l'hépatopathie (en particulier, la cirrhose biliaire primitive, la cholangite sclérosante primaire), ainsi que des médicaments utilisés comme agents prophylactiques et remèdes contre l'obésité, le foie graisseux et l'hépatite graisseuse, chacun contenant comme principe actif un composé benzothiazépine présentant une liaison thioamide et un substituant d'ammonium quaternaire représenté par la formule générale (1) suivante : A...ortho, B...méta, C...para. L'invention concerne en outre des remèdes et des agents prophylactiques de la cholestase accompagnant l'hépatopathie qui renferment comme principe actif un composé qui inhibe un transporteur d'acide biliaire iléal.
Mohri Mitsunobu
Sasahara Takehiko
Asahi Kasei Pharma Corporation
Goudreau Gage Dubuc
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