Heterocyclene derivatives

Details Heterocyclene derivatives Heterocyclene derivatives

C - Chemistry, Metallurgy

07

D

C07D 409/14 (2006.01) A61K 31/38 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01) C07D 407/04 (2006.01) C07D 409/04 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2045095

A B S T R A C T HETEROCYCLENE DERIVATIVES The invention concerns a heterocyclene derivative of the formula I Image I wherein Ar1 is optionally substituted phenyl, naphthyl or a 9- or 10-membered bicyclic heterocyclic moiety; A1 is a direct link to X1 or (1-3C)alkylene; X1 is oxy, thio, sulphinyl, sulphonyl or imino; Ar2 is optionally substituted 5-membered heterocyclene moiety; R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and R2 and R3 together form a group of the formula -A2-X2-A3- which, together with the carbon atom to which A2 and A3 are attached, defines a ring having 5 to 7 ring atoms, wherein each of A2 and A3 is (1-3C)alkylene and X2 is oxy, thio, sulphinyl or sulphonyl; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

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