Molecules for diagnostics and therapeutics

Details Molecules for diagnostics and therapeutics Molecules for diagnostics and therapeutics

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2381319

The present invention provides purified human polynucleotides for diagnostics and therapeutics (dithp). Also encompassed are the polypeptides (DITHP) encoded by dithp. The invention also provides for the use of dithp, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing dithp for the expression of DITHP. The invention additionally provides for the use of isolated and purified DITHP to induce antibodies and to screen libraries of compounds and the use of anti-DITHP antibodies in diagnostic assays. Also provided are microarrays containing dithp and methods of use.

La présente invention se rapporte à des polynucléotides humains purifiés utilisés à des fins diagnostiques et thérapeutiques (dithp). Elle se rapporte également aux polypeptides (DITHP) codés par ces dithp. Elle se rapporte également à l'utilisation de ces dithp, ou de leurs compléments, oligonucléotides ou fragments dans des analyses diagnostiques. L'invention se rapporte en outre à des vecteurs et cellules hôtes contenant ces dithp et permettant l'expression de DITHP. Elle concerne notamment l'utilisation de tels DITHP isolés et purifiés pour induire des anticorps et pour analyser des banques de composés ainsi que l'utilisation des anticorps anti-DITHP dans des analyses diagnostiques. L'invention se rapporte à des micro-ensembles contenant des dithp et à leur procédés d'utilisation.

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