Compositions and methods for modulation of immune responses

Details Compositions and methods for modulation of immune responses Compositions and methods for modulation of immune responses

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/04 (2006.01) A61K 38/08 (2006.01) C07K 7/00 (2006.01) C07K 7/06 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2456196

The present invention relates to a novel mechanism for modulation of immune response. More closely, the present invention relates to modulation of 5 CD94/NKG2 receptor function by HLA-E + bound peptides causing either inhibition or absence of inhibition of said receptors. In a preferred embodiment the invention relates to HLA-E binding hsp (heat shock protein) 60 peptides.

La présente invention concerne un nouveau mécanisme de modulation de réponse immune. Plus précisément, cette invention concerne la modulation de la fonction des récepteurs 5 CD94/NKG2 par des molécules HLA-E et des peptides de liaison entraînant soit l'inhibition soit l'absence d'inhibition de ces récepteurs. Un mode de réalisation préféré de l'invention concerne des peptides hsp 60 (protéine du stress) de liaison aux molécules HLA-E.

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