Molecular determinants of tropism and virulence in...

Details Molecular determinants of tropism and virulence in... Molecular determinants of tropism and virulence in...

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) C07H 21/02 (2006.01) C12N 7/00 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2379221

Recombinant enteroviruses for use as vaccines or vectors, which are modified in tropism or virulence, are disclosed. Also disclosed are DNA constructs comprising enterovirus-derived molecular determinants of tropism or virulence for use in targeting genes of interest to specific cells or tissues. The recombinant enteroviruses and DNA constructs comprise molecular determinants of tropism and virulence localized in specific domains of the 5'NTR of the enteroviral genome.

L'invention porte sur des entérovirus destinés à être utilisés comme vaccins ou vecteurs, et qui sont modifiés dans le tropisme ou la virulence. L'invention porte également sur des produits de recombinaison d'ADN comprenant des déterminants moléculaires dérivés des entérovirus du tropisme ou de la virulence et destinés à être utilisés dans des gènes ciblant des cellules ou tissus spécifiques. Les entérovirus de recombinaison et les produits de reconstruction d'ADN comprennent des déterminants moléculaires de tropisme et virulence localisés dans des domaines spécifiques de 5'NTR du génome entéroviral.

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