C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 205/04 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) A61K 31/433 (2006.01) A61K 31/4406 (2006.01) A61K 31/4995 (2006.01) A61K 31/506 (2006.01) C07D 207/16 (2006.01) C07D 211/56 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2721750
This invention relates to novel compounds of the Formula I, II, III, IHa, NIb, IV, Na, IVb, IVc, IVd, IVe, V, Va, Vb1 V1, V1a, VIb, VII, VIIa, VIIb, VIII, VIIIa, VIIIb, IX, IXa, X, and Xa, pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with the modulation or inhibition of 11 .beta.-HSD1 in mammals. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in the reduction or control of the production of Cortisol in a cell or the inhibition of the conversion of cortisone to Cortisol in a cell.
Cette invention concerne de nouveaux composés de formules I, II, III, IIIa, IIIb, IV, IVa, IVb, IVc, IVd, IVe, V, Va, Vb1 VI, Vla, VIb, VII, VIIa, VIIb, VIII, VIIIa, VIIIb, IX, IXa, X, et Xa, leurs sels pharmaceutiquement acceptables et leurs compositions pharmaceutiques, qui sont utiles pour le traitement thérapeutique des maladies associées à la modulation ou l'inhibition de la 11 ß-HSD1 chez des mammifères. L'invention concerne en outre des compositions pharmaceutiques des nouveaux composés et des procédés pour leur utilisation dans la réduction ou le contrôle de la production de cortisol dans une cellule ou l'inhibition de la conversion de cortisone en cortisol dans une cellule.
Claremon David A.
Singh Suresh B.
Tice Colin M.
Ye Yuanjie
Zhuang Linghang
Gowling Lafleur Henderson Llp
Vitae Pharmaceuticals Inc.
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