Dermatological use of vitamin d derivatives

Details Dermatological use of vitamin d derivatives Dermatological use of vitamin d derivatives

C - Chemistry, Metallurgy

07

C

C07C 401/00 (2006.01) A61K 31/59 (2006.01) C07D 309/12 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2210884

Vitamin D derivatives of formula (I), wherein: X is =CH2 or H,H; Y is a moiety (a) -CH(CH3)-(A)n-C(O)-OR1, (b) -CH(CH3)-CH2-O-C(O)-R2 or (c) -C(O)-OR1; A is - CH=CH- or CH2-CH2-; R1 is lower alkyl, cycloalkyl, cycloalkylmethyl, -CH2R3 or -CH2-CH2R3; R2 is lower alkyl, cycloalkyl or R3; R3 is hydroxy-lower alkyl, hydroxy-cycloalkyl or trifluoromethyl-hydroxy-nieder-alkyl; n is 0 or 1; and the dotted bond in the five-membered ring is optional; can be used in the treatment of dermatological conditions, in particular keratinization disorders.

Dérivés de la vitamine D de formule (I) dans laquelle: X est =CH¿2? ou H,H; Y est un fragment (a) -CH(CH¿3?)-(A)¿n?-C(O)-OR?1¿, (b) -CH(CH¿3?)-CH¿2?-O-C(O)-R?2¿ ou (c) -C(O)-OR?1¿; A est -CH=CH- ou CH¿2?-CH¿2?; R?1¿ est alkyle inférieur, cycloalkyle, cycloalkylméthyle, -CH¿2?R?3¿ ou - CH¿2?CH¿2?R?3¿; R?2¿ est alkyle inférieur, cycloalkyle ou R?3¿; R?3¿ est hydroxy-alkyle inférieur, hydroxy-cycloalkyle ou trifluorométhyle-hydroxy-alkyle inférieur; n est 0 ou 1; et les liaisons en pointillés du cycle à cinq éléments sont facultatives. Ces dérivés peuvent servir au traitement de troubles dermatologiques et en particulier de la kératinisation.

Affiliated with

Also associated with

Rating

Dermatological use of vitamin d derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dermatological use of vitamin d derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dermatological use of vitamin d derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1502800