Pichia methanolica secretory signal

Details Pichia methanolica secretory signal Pichia methanolica secretory signal

C - Chemistry, Metallurgy

12

N

C12N 15/81 (2006.01) C12N 1/16 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2534275

Novel Pichia methanolica secretory signal polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods of using are disclosed. Methods of producing large amounts of recombinant proteins by employing DNA constructs having a polypeptide of interest preceded by a novel Pichia methanolica secretory signal sequence.

L'invention concerne de nouveaux polypeptides signaux sécréteurs de Pichia methanolica, des polynucléotides codant lesdits polypeptides, et des compositions et des procédés d'utilisation de ces derniers. L'invention concerne également des procédés de production de grandes quantités de protéines recombinées comprenant l'utilisation de constructions d'ADN présentant un polypeptide d'intérêt précédé par une nouvelle séquence de signaux sécréteurs de Pichia methanolica.

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