Retinoids and their use in treating skin diseases and leukemia

Details Retinoids and their use in treating skin diseases and leukemia Retinoids and their use in treating skin diseases and leukemia

C - Chemistry, Metallurgy

07

C

C07C 69/773 (2006.01) A61K 31/235 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07C 69/82 (2006.01) C07C 69/86 (2006.01) C07D 213/80 (2006.01) C07D 239/42 (2006.01) C07D 241/26 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2119571

2119571 9306086 PCTABS00021 Compounds of formula (I) or (II) and pharmaceutically acceptable salts and prodrugs thereof, wherein R1 is C1 to C8 alkyl and Q is selected from (a), (b), (c), (d), (e) and (f), wherein Y is selected from (III), (IV), (V), (VI), (VII), (VIII), (IX) and (X) and Z is selected from groups of formula (XI), with the pharmaceutically acceptable salts and prodrugs of the aforesaid formula I or II final products being derived from the hereinbefore described Y and Z acid groups. These compounds are useful in treating aging skin, and also skin conditions such as psoriasis, acne and related disorder of keratinization and epithelial differentiation, as well as skin tumors.

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