A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/714 (2006.01) A61K 9/10 (2006.01) A61P 7/06 (2006.01)
Patent
CA 2644555
A method of manufacturing a stable nanosuspension for delivery of a biologically active agent, particularly vitamin B-12, into the bloodstream of a subject is disclosed. A Nanofluidizable mixture containing vitamin B-12 is initially formed and processed via a nanofluidization process to form the stable nanosuspension, which may be administered via the transmucosal membranes or other suitable routes of administration. This product demonstrates increased bioavailability, enhanced period of onset, and enhanced stability for a controlled-release product.
La présente invention concerne un procédé de fabrication d'une nanosuspension stable pour l'administration d'un agent biologiquement actif, notamment la vitamine B-12, dans le flux sanguin d'un sujet. Un mélange nanofluidisable contenant de la vitamine B-12 est initialement formé et traité par un procédé de nanofluidisation en vue de former la nanosuspension stable, qui peut être administrée par le biais des membranes transmuqueuses ou d'autres voies appropriées. Ce produit montre une biodisponibilité améliorée, un meilleur délai d'action et une plus grande stabilité pour un produit à libération contrôlée.
Gerike Michael
Van de Casteele Russell
Finlayson & Singlehurst
Health Plus International Inc.
LandOfFree
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