Modulation of rhamm (cd168) for selective adipose tissue...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 31/7105 (2006.01) A61K 31/713 (2006.01) A61K 38/17 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2670320

Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described.

L'invention concerne des méthodes et des compositions de modulation de Rhamm, également connu sous le nom de CD 186, et ses effets sur la cicatrisation des plaies, la différenciation musculaire, la densité osseuse et l'adipogenèse grâce à sa capacité de régulation de la différenciation des cellules souches mésenchymateuses. L'invention concerne des compositions et des méthodes de blocage de la fonction de Rhamm pour augmenter de manière sélective la graisse sous-cutanée mais non viscérale. L'invention concerne également des compositions et des méthodes de modulation de Rhamm dans la cicatrisation des plaies.

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