A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/407 (2006.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01) C12N 5/08 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2214503
A method for preparing alloactivated human donor lymphocytes for subsequent treatment of a tumor in a human patient, comprising the steps of: a) coculturing donor lymphocytes from a human donor ex vivo with leukocytes from the human patient so as to alloactivate the donor lymphocytes; and b) harvesting the alloactivated donor lymphocytes and preparing the alloactivated donor lymphocytes for human administration at a time after initiation of the coculturing when the alloactivated donor lymphocytes, upon implantation .in the bed of a solid tumor in the patient, are effective in the treatment of the tumor. This method is of use in treatment of glioblastoma in humans.
Méthode de traitement d'un mammifère atteint d'une tumeur consistant à lui administrer des lymphocites donneurs allogènes co-cultivés en présence de lymphocytes dans des conditions permettant l'alloactivation des lymphocytes donneurs qu'il est préférable d'introduire dans la lésion. Ladite méthode s'applique de préférence au traitement des glioblastomes chez l'homme.
Granger Gale A.
Borden Ladner Gervais Llp
The Regents Of The University Of California
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