C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12N 15/62 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2246300
The present invention provides methods and compositions for identifying inhibitors of the interaction between phosphopeptide binding pairs, i.e., a protein domain having at least one phosphopeptide binding domain and the phosphorylated ligands that bind these domains. These inhibitors may be used for pharmaceutical compositions and in therapeutic treatments for diseases in which a phosphopeptide domain binding is implicated.
La présente invention se rapporte à des procédés et à des compositions qui permettent d'identifier des inhibiteurs de l'interaction entre des paires de fixation de phosphopeptides, c'est à dire un domaine protéique ayant au moins un domaine de fixation de phosphopeptides, et les ligands phosphorylés qui se lient à ces domaines. Ces inhibiteurs peuvent être utilisés dans des compositions pharmaceutiques et des traitements thérapeutiques de maladies dans lesquelles un domaine de fixation de phosphopeptides est impliqué.
Ariad Pharmaceuticals Inc.
Borden Ladner Gervais Llp
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