Exendin fusion proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07K 14/575 (2006.01) C07K 14/605 (2006.01) C07K 14/79 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2658654

The invention provides fusion proteins comprising an exendin-4 fused to a transferrin (Tf) via a polypeptide linker, as well as corresponding nucleic acid molecules, vectors, host cells, and pharmaceutical compositions. The invention also provides the use of the exendin-4/Tf fusion proteins for treatment of Type Il diabetes, obesity, and to reduce body weight.

L'invention concerne des protéines de fusion comprenant une extendine-4 fusionnée à une transferrine (Tf) par un liant à base de polypeptide, ainsi que des molécules d'acide nucléique, des vecteurs, des cellules hôtes et des compositions pharmaceutiques correspondants. L'invention concerne également l'utilisation de protéines de fusion d'extendine-4/Tf dans le traitement du diabète de type Il, de l'obésité, et afin de réduire le poids corporel.

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