Chimeric hirudin proteins

Details Chimeric hirudin proteins Chimeric hirudin proteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/58 (2006.01) A61K 47/48 (2006.01) A61P 7/02 (2006.01) C07K 14/815 (2006.01) C07K 17/00 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2686135

The present invention relates to a chimeric hirudin protein comprising a carrier attached to the N-terminus of hirudin, with an intervening plasmin cleavage site. The chimeric hirudin protein contains a relatively inactive form of hirudin. However, when such chimeric hirudin protein being being cleaved by plasmin in the vicinity of a clot and, ultimately causing the release of active hirudin and the reduction of the size of the clot. The chimeric hirudin protein exhibited much slower clearance in mice than unfused wild-type hirudin.

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