Stable solid oral dosage co-formulations

Details Stable solid oral dosage co-formulations Stable solid oral dosage co-formulations

A - Human Necessities

61

K

A61K 31/343 (2006.01) A61K 9/10 (2006.01) A61K 31/4418 (2006.01)

Patent

CA 2737481

Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics of drugs that undergo in vivo degradation by cytochrome P450 enzymes. Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Specifically, methods of inhibiting metabolic degradation of atazanavir sulphate for administering to a patient suffering from HIV infection are disclosed.

L'invention porte sur des compositions pharmaceutiques qui peuvent servir de stimulants pour améliorer la pharmacocinétique de médicaments qui subissent une dégradation in vivo par des enzymes du cytochrome P450. L'invention porte sur des procédés d'inhibition des enzymes du cytochrome P450 qui peuvent être utilisées pour améliorer le traitement de maladies par la prévention d'une dégradation de médicaments ou autres molécules par le cytochrome P450. Spécifiquement, l'invention porte sur des procédés consistant à inhiber une dégradation métabolique d'un sulfate d'atazanavir pour une administration à un patient souffrant d'une infection par le VIH.

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