Composition and method for the release of protected peptides...

Details Composition and method for the release of protected peptides... Composition and method for the release of protected peptides...

C - Chemistry, Metallurgy

07

K

C07K 1/12 (2006.01) C07C 31/38 (2006.01) C07C 31/40 (2006.01)

Patent

CA 2651070

The present invention provides a composition and a method for cleaving a peptide from a solid support resin. Hydrochloric acid in an organic water miscible solvent is used to cleave the peptide-resin attachment. Optionally, trifluoroethanol or hexafluoroisopropanol may be added to the cleavage composition to improve results. When using the present cleavage composition, an evaporation or other step to remove carboxylic byproducts is not necessary following the cleavage reaction. After the resin is filtered out of the cleavage mixture, the peptide may be immediately precipitated with water.

L'invention porte sur une composition et un procédé de séparation d'un peptide d'avec une résine support solide. À cet effet on utilise de l'acide hydrochlorique dans un solvant organique miscible à l'eau. On peut facultativement ajouter du trifluoroéthanol ou de l'hexafluoroisopropanol pour améliorer les résultats. Avec cette composition il n'est plus nécessaire de procéder après la séparation à une évaporation ou à d'autres opérations. Après filtrage de la résine, le peptide restant peut être immédiatement précipité dans l'eau.

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