Treatment of oncologic tumors with an injectable formulation...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/00 (2006.01) A61K 31/122 (2006.01) A61K 31/203 (2006.01) A61K 31/35 (2006.01) A61K 31/365 (2006.01) A61K 31/4184 (2006.01) A61K 45/06 (2006.01) A61K 47/36 (2006.01) A61K 47/48 (2006.01) C07D 313/00 (2006.01)

Patent

CA 2344316

Novel pharmaceutical formulations for treating a cellular proliferative disease are provided comprising: a therapeutically effective amount of a Golgi apparatus disturbing agent; a biocompatible carrier; and a solvent. In preferred formulations, the Golgi apparatus disturbing agent is brefeldin A (BFA) and the biocompatible carrier is a polymer such as chitin or chitosan. Methods of treating cellular proliferative diseases using the pharmaceutical formulations are also described.

L'invention concerne des formulations pharmaceutiques permettant de traiter une maladie à prolifération cellulaire, qui comprennent les élément suivants: quantité thérapeutiquement efficace d'agent perturbateur pour appareil de Golgi, vecteur biocompatible, et solvant. De préférence, l'agent susmentionné est une bréfeldine (BFA), et le vecteur est un polymère du type chitine ou chitosane. L'invention concerne également des procédés relatifs au traitement des maladies à prolifération cellulaire, qui consistent à utiliser les formulations décrites.

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