Aggrecanase-1 and -2 peptide substrates and methods

Details Aggrecanase-1 and -2 peptide substrates and methods Aggrecanase-1 and -2 peptide substrates and methods

C - Chemistry, Metallurgy

12

N

C12N 9/50 (2006.01) A61K 38/00 (2006.01) C07K 1/00 (2006.01) C12N 9/64 (2006.01) C12N 15/09 (2006.01) C12Q 1/37 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2473513

The present invention describes synthetic peptide substrates of the metalloproteases, agggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases.

L'invention concerne des substrats peptidiques synthétiques de métalloprotéases, d'aggrécanase-1 et/ou -2 appropriés à des analyses d'activité enzymatique. L'invention concerne également des procédés mettant en oeuvre lesdits peptides afin de découvrir des agents pharmaceutiques qui modulent lesdites protéases.

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