A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01)
Patent
CA 2503284
The present invention provides methods and formulations for the treatment and prevention of cerebrovascular and cardiovascular diseases and disorders. The present invention is based, at least in part, on the discovery that administering to a subject a formulation comprising an agonist of endothelial nitric oxide synthase (eNOS), such as an HMG-CoA reductase inhibitor, and a formulation comprising a precursor of NO, such to as L-arginine, may be used to treat or prevent cerebrovascular and/or cardiovascular diseases or disorders.
La présente invention concerne des procédés et des préparations servant au traitement et à la prévention de maladies et de troubles cérébrovasculaires et cardiovasculaires. La présente invention repose, du moins partiellement, sur la découverte que le fait d'administrer à un patient une préparation contenant un agoniste de la monoxyde d'azote synthase endothéliale (NOSe), tel qu'un inhibiteur de la HMG-CoA réductase, ainsi qu'une préparation contenant un précurseur du monoxyde d'azote, tel que la L-arginine, peut servir à traiter ou à prévenir les maladies ou les troubles cérébrovasculaires et/ou cardiovasculaires.
Enos Pharmaceuticals Inc.
Palmetto Pharmaceuitcals Llc
Riches Mckenzie & Herbert Llp
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