Suramin and derivatives thereof as topical microbicide and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/185 (2006.01) A61F 6/06 (2006.01) A61P 15/18 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2477734

The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravaginally. Suramin compositions that include an antimicrobial agent and/or a sperm-function inhibitor are also provided and may advantageously be used in the methods of the invention. A method of simultaneously inhibiting STDs and preventing pregnancy is also provided. Devices impregnated or coated with the topical suramin compositions are further disclosed and may be used to apply the compositions described herein.

L'invention porte: sur des procédés inhibant les MST par administration topique de suramine ou de l'un de ses dérivés sur un site réel ou potentiel d'infection; sur des procédés prévenant la grossesse par application intravaginale de suramine ou de l'un de ses dérivés; sur des préparations de suramine contenant un microbicide et/ou un inhibiteur de la fonction spermatique pouvant avantageusement servir dans le cadre des procédés de l'invention; sur un procédé assurant simultanément l'inhibition des MST et la prévention de la grossesse; sur des dispositifs imprègnes ou revêtus de préparations topiques de suramine et pouvant servir à appliquer lesdites préparations.

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