C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 48/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2318380
This invention provides methods by which test substances can be screened for their ability to inhibit, enhance or eliminate double minute (DM) or extrachromosomal DNA by micronucleation in cells. This invention also provides a method for inducing maturation or death of a cell having the capacity to generate micronuclei. It also provides a method of treating a disease in a subject, the cells correlated with the disease having DM and extrachromosomal DNA as well as the capacity to generate micronuclei to capture them. Further provided is a method of detecting chromosomal and extrachromosomal DNA in a cell.
L'invention concerne des procédés permettant le criblage de substances à tester en fonction de leur aptitude à inhiber, stimuler ou éliminer l'ADN double-minute (DM) ou extrachromosomique par micronucléation dans des cellules. Cette invention concerne également un procédé permettant d'induire la maturation ou la mort d'une cellule présentant la capacité à générer des micronoyaux. Elle concerne également un procédé permettant de traiter une maladie chez un sujet, les cellules associées à la maladie présentant un ADN double-minute (DM) et un ADN extrachromosomique et présentant la capacité à générer des micronoyaux pour capturer lesdits ADN. L'invention concerne également un procédé de détection d'ADN chromosomique et d'ADN extrachromosomique dans une cellule.
Kanda Teru
Shepard H. Michael
Shimizu Noriaki
Wahl Geoffrey M.
Goudreau Gage Dubuc
Newbiotics Inc.
The Salk Institute
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