Thymosin augmentation of genetic immunization

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/16 (2006.01) A61K 38/22 (2006.01) A61K 39/29 (2006.01) A61K 39/39 (2006.01) A61K 45/00 (2006.01) C07K 14/18 (2006.01)

Patent

CA 2464795

This invention describes the use of thymosin to augment cellular immune responses to hepatitis C virus. Methods for immunizing a subject susceptable to hepatitis C virus infection against such infection, comprising administering to the subject one or more polynucleotides encoding one or more hepatitis C virus peptides, in combination with one or more thymosins, are disclosed. Compositions suitable for immunizing against hepatitis C virus, comprising one or more polynucleotides encoding one or more hepatitis C virus peptides, and one or more thymosins, are also disclosed.

La présente invention décrit l'utilisation d'une .alpha.-thymosine pour augmenter les réponses immunitaires cellulaires au virus de l'hépatite C. L'invention traite également de procédés permettant d'immuniser un sujet risquant d'être infecté par le virus de l'hépatite C contre cette infection. Ce procédé consiste à administrer au sujet un ou plusieurs polynucléotides codant un ou plusieurs peptides du virus de l'hépatite C, en association avec une ou plusieurs .alpha.-thymosines. L'invention traite de compositions assurant une immunité contre le virus de l'hépatite C. Ces compositions comprennent un ou plusieurs polynucléotides codant un ou plusieurs peptides du virus de l'hépatite C, et une ou plusieurs .alpha.-thymosines.

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